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ON123300 is a potent and multi-targeted kinase inhibitor with IC50 of 3.9 nM, 5 nM, 26 nM, 26 nM, 9.2 nM and 11nM for CDK4, Ark5, PDGFRβ, FGFR1, RET, . This study describes the characterization of a novel kinase inhibitor, ON123300, which inhibits CDK4/6 (cyclin-dependent kinases 4 and 6) and . ON123300 is a potent and multi-targeted kinase inhibitor with IC50 of 3.9 nM, . Territorial Availability: Available through Bertin Technologies only in Europe. ON-123300 is a multi-kinase inhibitor. 1,2 It inhibits ARK5, Cdk4, and Cdk6 (IC50s = 3.87, 9.82, and 4.95 nM, respectively) as well as FYN, PDGFRβ, Abl, and . Biochemical assays indicated that ON123300 was a strong inhibitor of Ark5 and CDK4, as well as growth factor receptor . European journal of cancer • 2013 . ON 123300, a small molecule dual inhibitor of the c-MYC activated kinases ARK5 and CDK4/6, is being . European Journal of Drug Metabolism and… 2015. 7. 15. – We examined the effects of PD0332991 and ON123300 on cell cycle . Dreyling M, Ferrero S, Vogt N, Klapper W, European Mantle Cell . 2019. 5. 5. – Article in European Journal of Drug Metabolism and Pharmacokinetics . ON 123300 (bislactate salt) pharmacokinetics were evaluated . Onconova Therapeutics, Inc. is focused on discovering and developing novel small molecule drug candidates to treat cancer.
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